Disease-associated microglia signature genes are up-regulated during photoreceptor degeneration

Retinal degeneration is a collection of devastating conditions with progressive loss of vision which often lead to blindness. Research on retinal microglial cells offers great therapeutic potential in deterring the progression of the condition. This study explored the mechanisms underlying the TREM2-mediated protective function of activated microglial cells during retinal degeneration. A significant upregulation of disease-associated microglia signature genes was observed during photoreceptor degeneration. RNA-Seq on whole-retina samples from rd10 and wild-type mouse retina. Two biological replicates of each.