Dynamics of vesicles in dense pools studied by XPCS-microrheology (cont’d): extension to synaptic vesicles and active systems

We propose to study the dynamics of synaptic vesicles and of artificial lipid vesicles in dense vesicle pools by X-ray photon correlation spectroscopy (XPCS), extending our previous work on artificial lipid vesicles. Pools are aggregates of vesicles which are clustered together by proteins causing an attractive interaction. We are interested in the short range (hindered) diffusion of vesicles which are at least partially arrested in the pool. The dynamics takes place on much slower timescales than free diffusion, and can also be distinguished from free diffusion via the q-dependence.