Supplemental Figure S1: Contour-enhanced funnel plots

Supplemental Figure S1. Contour-enhanced funnel plots created for A) colostral IgG concentration in heat-treated versus raw colostrum, B) viscosity of colostrum in heat-treated versus raw colostrum and C) serum IgG concentration in calves fed heat-treated colostrum versus calves fed raw colostrum for all studies included in each meta-analysis. The symmetrical distribution of trials included in the meta-analysis (grey dots) around the mean difference suggests no publication bias. When asymmetry was identified the trials perceived as missing (hollow dots) were filled by trim-and-fill. When studies that appear to be missing were in low statistical significance areas, asymmetry was likely due to publication bias (Palmer et al., 2008).补充图S1。为各项荟萃分析纳入的全部研究绘制的等高线增强漏斗图：A为热处理初乳与生鲜初乳的初乳IgG浓度，B为热处理初乳与生鲜初乳的初乳黏度，C为饲喂热处理初乳的犊牛与饲喂生鲜初乳的犊牛的血清IgG浓度。荟萃分析纳入的试验（灰色圆点）在均数差周围呈对称分布，提示无发表偏倚。当观察到分布不对称时，采用剪补法（trim-and-fill）补全被判定为缺失的试验（空心圆点）。若缺失的研究处于统计显著性较低的区域，则分布不对称大概率由发表偏倚所致（Palmer等，2008）。