ChIP-seq with DNA methylation inhibitor in HCT116
收藏NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE108205
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资源简介：
Heterochromatin conformation is essential for endogenous retroviruses (ERVs) silencing. However, extensive maps of heterochromatin modifications H3K9me2/3 at ERV regions have not yet been provided in human cancer cells. Our ChIP-seq results showed that ERVs tend to be concentrated in regions of heterocromatin, which are marked by the presence of H3K9me3. We also observed dramatic increases H3K9me2/3 in the ERVs after transient treatment with DNA methylation inhibitor. ChIP-seq using H3K9me2 and H3K9me2 antibodies were performed in the human colon cancer cell line HCT116, following DNA methylation inhibitor treatment.
创建时间：
2019-03-26
