Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S)-17-((4-isopropylphenyl)amino)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S)-17-((4-isopropylphenyl)amino)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol Descriptor: (9beta,13alpha,17beta)-17-{[4-(propan-2-yl)phenyl]amino}estra-1(10),2,4-trien-3-ol, Estrogen receptor, Nuclear receptor coactivator 2 Authors: Nwachukwu, J.C, Erumbi, R, Srinivasan, S, Bruno, N.E, Nowak, J, Izard, T, Kojetin, D.J, Elemento, O, Katzenellenbogen, J.A, Nettles, K.W. Deposit date: 2016-10-13 Release date: 2017-01-18 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.543 Å) Cite: Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chem Biol, 24, 2017

ER-α配体结合结构域（Y537S）与雌二醇衍生物(8S,9S,13S,14S)-17-((4-异丙基苯基)氨基)-13-甲基-7,8,9,11,12,13,14,15,16,17-十氢-6H-环戊并[a]菲-3-醇形成复合物的晶体结构
结构描述符：(9β,13α,17β)-17-{[4-(异丙基)苯基]氨基}雌甾-1(10),2,4-三烯-3-醇、雌激素受体（Estrogen receptor）、核受体辅激活因子2（Nuclear receptor coactivator 2）
作者：Nwachukwu, J.C.、Erumbi, R.、Srinivasan, S.、Bruno, N.E.、Nowak, J.、Izard, T.、Kojetin, D.J.、Elemento, O.、Katzenellenbogen, J.A.、Nettles, K.W.
沉积日期：2016-10-13；发布日期：2017-01-18；最后修改日期：2024-03-06
实验方法：X射线衍射（分辨率2.543埃）
引用文献：《配体对ERα的系统结构生物学分析可预测细胞对环境雌激素与抗激素治疗的应答》，发表于《细胞化学与生物学（Cell Chem Biol）》，2017年，第24卷