Gene expression profile at single cell level of hematopoietic stem cells from bone marrow in aging mice.

Age-related physiological decline emerges at different chronological ages across individuals. We compared mice that exhibited early or delayed hematopoietic aging at the same chronological age by scRNA-seq. Overall design: Hematopoietic stem cells (HSCs) from mice that exhibited early or delayed hematopoietic aging at the same chronological age were analyzed by scRNA-seq.