Genome-wide analysis of t(14;18)-negative/BCL2 expression-negative FL

A subset of FL in adults are negative for t(14;18) translocation and BCL2 expression The tumor shows low grade cytology and lack both BCL2 expression and t(14;18) translocation. The genetic alterations involved in the pathogenesis of FL without t(14;18)-negative translocation and BCL2 expression are not well known. The aim of this study was to perform a complete genetic characterization of t(14;18)-negative FL. Fifty-seven cases with consensus diagnosis of FL and absense of t(14;18) by fluorescence in situ hybridization and without BCL2 expression by immunohistochemistry, were analyzed by copy number (CN) array and targeted sequencing analyses of genes associated with FL pathogenesis.