Expression data from 18-month old rats. Expression data from 18-month old rats

Multiple mechanisms and pathophysiological changes after anesthesia, such as brain aging and neurodegenerative diseases. And the gene transcription patterns and modulation networks after general anesthesia remains to be elucidated. We used microarrays to detail the global programme of gene expression in rats after sevoflurane anesthesia and identified distinct classes of changed. Overall design: Eighteen-month old male Sprague-Dawley rats were subjected to 2.5% sevoflurane (case group) or 100% oxygen (control group) exposure for 4 h. The hippocampus was selected for RNA extraction and hybridization on Affymetrix microarrays.