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Gene Expression Changes in Definitive Endoderm in response to GATA6-depletion (Affymetrix)

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE81898
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GATA6 is required for proper definitive endoderm formation. The mechanism of this process is poorly understood We used microarrays to identify genes whose expression is altered upon GATA6-depletion Stable lentiviral or control cell lines were differentiated to various stages of definitive endoderm. Rescue lines were differentiated to definitive endodermin the presence of doxycycline to induce shRNA-resistant GATA6 transgene expression. Using this system we identified genes whose expression was altered upon GATA6 depletion during definitive endoderm differentiation.
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2018-08-23
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