Structure of FPT bound to DATFP-DH-GPP
收藏Protein Data Bank Japan2023-09-06 更新2026-03-21 收录
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Structure of FPT bound to DATFP-DH-GPP Descriptor: (2S,6E)-8-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-2,6-dimethyloct-6-en-1-yl (2S)-3,3,3-trifluoro-2-hydrazinopropanoate, Farnesyltransferase, CAAX box, ... Authors: Hovlid, M.L, Edelstein, R.L, Henry, O, Ochocki, J, DeGraw, A, Lenevich, S, Talbot, T, Young, V, Hruza, A.W, Lopez-Gallego, F, Labello, N.P, Strickland, C.L, Schmidt-Dannert, C, Distefano, M.D. Deposit date: 2009-11-23 Release date: 2009-12-22 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Synthesis, properties, and applications of diazotrifluropropanoyl-containing photoactive analogs of farnesyl diphosphate containing modified linkages for enhanced stability. Chem.Biol.Drug Des., 75, 2010
与DATFP-DH-GPP配体结合的法尼基转移酶（Farnesyltransferase, FPT）结构：(2S,6E)-8-{[(R)-羟基(膦酰氧基)膦酰基]氧基}-2,6-二甲基辛-6-烯-1-基 (2S)-3,3,3-三氟-2-肼基丙酸酯，法尼基转移酶，CAAX盒，……
作者：Hovlid, M.L.、Edelstein, R.L.、Henry, O.、Ochocki, J.、DeGraw, A.、Lenevich, S.、Talbot, T.、Young, V.、Hruza, A.W.、Lopez-Gallego, F.、Labello, N.P.、Strickland, C.L.、Schmidt-Dannert, C.、Distefano, M.D.
沉积日期：2009-11-23；发布日期：2009-12-22；最后修改日期：2023-09-06
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.05 Å
引用文献：含重氮三氟丙酰基的法尼基二磷酸光活性类似物的合成、性质及应用——通过修饰连接键提升稳定性，《Chem.Biol.Drug Des.》，第75卷，2010年
创建时间：
2009-11-23
