five

CDK12 isogenic knockouts in prostate cancer

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP525071
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The goal of this project is to generate isogenic prostate cancer cells that are deficient in the protein CDK12 using CRISPR/Cas9, which leads to indels that cause premature stop codons in the CDK12 gene. Cells were single-cell cloned from a polyclonal population after transfection with Cas9 and the sgRNA targeting CDK12. We describe multiple CDK12 KO clones that were generated.
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2024-08-10
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