Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils

Nanobody with WIW inserted in CDR3 loop to Inhibit Growth of Alzheimer's Tau fibrils Descriptor: GLYCEROL, Nanobody with WIW insert in CDR3 loop to target tau fibrils Authors: Abskharon, R, Sawaya, M.R, Cascio, D.C, Eisenberg, D.S. Deposit date: 2023-01-05 Release date: 2023-10-04 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc.Natl.Acad.Sci.USA, 120, 2023在CDR3环（CDR3 loop）中插入WIW序列以抑制阿尔茨海默病Tau纤维（Tau fibrils）生长的纳米抗体（Nanobody） 描述项：甘油（GLYCEROL），在CDR3环中插入WIW序列以靶向Tau纤维的纳米抗体 作者：Abskharon, R、Sawaya, M.R、Cascio, D.C、Eisenberg, D.S. 保藏日期：2023-01-05 发布日期：2023-10-04 最后修改日期：2024-10-30 实验方法：X射线衍射（X-RAY DIFFRACTION）（分辨率1.4 Å） 引用文献：基于结构设计的可抑制阿尔茨海默病患者提取Tau纤维种子形成的纳米抗体. Proc.Natl.Acad.Sci.USA, 120, 2023