Probabilities of completing the YHT in the condition pH = 1 and Farnesol = Temperature = 0, under single-node interventions or WT.

Transition probabilities are estimated from 500 simulated trajectories starting from the yeast attractor corresponding to the given environment (see Fig 2). When a perturbed system’s attractor is different from the WT attractor, it is classified into a phenotype (attractor group) by similar criteria as in Fig 2; see S2 Fig for more details.