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The RNA binding protein IGF2BP3 promotes hematopoietic progenitor cell proliferation by targeting leukemogenic pathways

ChEBI2016-01-16 更新2026-07-12 收录

白血病机制研究

造血干细胞调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-76931 数据链接链接失效反馈

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The RNA binding protein IGF2BP3 promotes hematopoietic progenitor cell proliferation by targeting leukemogenic pathways

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创建时间：

2016-01-16

造血干细胞调控

转录因子功能分析

To investigate the role of the transcription factor ERG in hematopoiesis we generated Erg heterozygous knockout and conditional Erg knockout mice. We found that several hematopoietic cell types were d

NIAID Data Ecosystem60

Systematic screening of chromatin factors identifies divergent roles across haematopoiesis and leukaemia [scRNA-Seq]. Systematic screening of chromatin factors identifies divergent roles across haematopoiesis and leukaemia [scRNA-Seq]

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Cellular differentiation-trajectories require extensive alterations in chromatin structure and function, elicited by a diverse array of chromatin-factors (CFs). Using haematopoiesis as a model-system,

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Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

造血干细胞调控

基因功能研究

Musashi 2 is a regulator of the hematopoietic stem cell compartment identified by a retroviral insertion screen and knockout mice

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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [BcorKrasRNA-seq]

白血病机制研究

骨髓转录组

Investigation of the transcriptional profile of Bcor?E9-10KrasG12D myeloid progenitors Overall design: Splenocytes from Bcor?E9-10KrasG12D mice were transplanted into PTPRCA recipients, after 4 weeks

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In Vivo Analysis of Retroviral Enhancer Mutations in Hematopoietic Cells: SP1/EGR1 and ETS/GATA Motifs Contribute to Long Terminal Repeat Specificity

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逆转录病毒增强子功能

The objective of this work was to identify, in the context of chromosomally integrated DNA, the contribution of defined transcription factor binding motifs to the function of a complex retrovirus enha

PubMed Central40

The RNA binding protein IGF2BP3 promotes hematopoietic progenitor cell proliferation by targeting leukemogenic pathways

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