The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates

The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates Descriptor: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... Authors: Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. Deposit date: 2014-01-16 Release date: 2015-01-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published

本数据集聚焦赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶（Farnesyl Pyrophosphate Synthase，FPPS），研究其催化活性、晶体结构以及含氮双膦酸盐（nitrogen containing bisphosphonates）对该酶的抑制作用。
数据集描述项：3-甲基丁-3-烯基三氢二磷酸（3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE）、法尼基焦磷酸合酶、镁离子（MAGNESIUM ION）等
作者：Tsoumpra, M.K、Barnett, B.L、Muniz, J.R.C、Walter, R.L、Ebetino, F.H、von Delft, F、Russell, R.G.G、Oppermann, U、Dunford, J.E.
存档日期：2014-01-16
发布日期：2015-01-21
最后修改日期：2023-09-20
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.1埃（2.1 Å）
引用文献：《赖氨酸200与苯丙氨酸239位点突变的法尼基焦磷酸合酶的催化活性、晶体结构以及含氮双膦酸盐对其抑制作用》，待发表。