Dose Finding and Pharmacokinetics/Pharmacodynamics Study of Apatinib in the Treatment of Advanced Colorectal Cancer
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https://www.omicsdi.org/dataset/ecrin-mdr-crc/2120259
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RATIONALE:
Apatinib is a tyrosin-inhibitor agent targeting at vascular endothelial growth factor receptor (VEGFR), and it’s anti-angiogenesis effect has been viewed in preclinical tests. The investigators’ phase I study has shown that the drug’s toxicity is manageable.
PURPOSE:
1. Studying how well Apatinib works in treating patients.
2. Finding the efficacy and safety of 500 mg or 750mg Apatinib.
3. Pharmacokinetics/Pharmacodynamics(PK/PD).
4. Exploring new outcome measures of antiangiogenic drugs.
创建时间：
2011-04-15
