Variability of RRate: breathing and quality data

Background: Respiratory rate is difficult to measure, especially in neonates who have an irregular breathing pattern. The World Health Organisation recommends a one minute count, but there is limited data to support this length of observation. We sought to evaluate agreement between the respiratory rate (RR) derived from capnography in neonates, over 15 seconds, 30 seconds, 120 seconds and 300 seconds, against the recommended 60 seconds rate. Methods: Neonates at two hospitals in Nairobi were recruited and had capnograph waveforms recorded using the Masimo Rad 97. A single high quality 5 minute epoch was randomly chosen from each subject. For each selected epoch, the mean RR was calculated using a breath-detection algorithm applied to the waveform. The RR in the first 60 seconds was compared to the mean RR measured over the first 15 seconds, 30 seconds, 120 seconds, full 300 seconds, and last 60 seconds. We calculated bias and limits of agreement for each comparison and used Bland-Al...背景：呼吸频率的测量颇具难度，对于呼吸节律不规则的新生儿而言尤为如此。世界卫生组织（World Health Organisation）推荐采用1分钟计数法，但支持该观测时长的相关数据较为有限。本研究旨在评估新生儿基于二氧化碳描记法（capnography）测得的呼吸频率（RR），分别以15秒、30秒、120秒及300秒为观测时长的结果，与推荐的60秒测量结果之间的一致性。 方法：招募内罗毕两家医院的新生儿，使用Masimo Rad 97监护仪记录其二氧化碳描记波形。从每名受试者中随机选取一段高质量的5分钟记录时段。针对每一段选定的时段，采用应用于波形的呼吸检测算法计算平均呼吸频率。将前60秒测得的呼吸频率，分别与前15秒、前30秒、前120秒、完整300秒以及最后60秒的平均呼吸频率进行对比。本研究计算了每一组对比的偏差与一致性界限，并采用Bland-Altman分析法。