Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors - Supplemental Data Tables

Supplemental Data Table - Metabolome.xlsx - a complete list of measured metabolites for Ramos and HBL2 cell lines. Peak area values for normoxic and hypoxia-adapted cells in triplicates. Mean log 2 fold change and adjusted P values are provided for all metabolites except those under the limits of detection.

Supplemental Data Table - Transcriptome Differential Expression.xlsx - the tables of all transcripts detected in hypoxia-adapted HBL2 and Ramos lymphoma cell lines compared to normoxic controls. Fold change and log 2 fold change, log 2 CPM, F statistic, P value and False Discovery Rate (FDR) were calculated using EdgeR package. Last column shows if a transcript was significantly up- or downregulated or not (ns).

Supplemental Data Table - Transcriptome Gene Set Analysis.xlsx - the tables of the gene set enrichment analysis of Reactome pathways in hypoxia-adapted HBL2 and Ramos lymphoma cell lines compared to normoxic controls.

Supplemental Data Table - Proteome Differential Expression.xlsx - the tables of proteins detected and differentially expressed in hypoxia-adapted HBL2 and Ramos lymphoma cell lines compared to normoxic controls.

Supplemental Data Table - Cell lines SNV characterization.xlsx - the tables of mutations (single nucleotide variations and short indels) detected in four tested lymphpoma cell lines and corresponding primary tumor (PT) samples. AF_CTRL - allelic frequency (0..1) in healthy control DNA from the patient, AF_PT - allelic frequency in primary tumor, AF_PDCL - allelic frequency in patient-derived cell line. DP - total sequence depth, TLOD - Log odds that the variant is present in the tumor sample relative to the expected noise. Gencode and HGNC annotation columns are output of the Funcotator analysis. SNVs were detected using Mutect2 as a part of GATK 4.6.0.0 somatic variat calling pipeline.