RNA sequencing results from SNA-high and SNA-low, young and old murine T cells

Glycans regulates cellular function, yet how aging impacts the glycocalyx
remains unclear. We investigate changes in immune cell glycocalyx
with age and find that α2,6-linked sialic acid, a glycan
epitope associated with inhibitory signaling, is downregulated in
T cells from old animals. Through functional experiments and RNA
sequencing, we found that this reduction is tightly correlated
with age-associated accumulation of effector T cells, which have little to
no α2,6-linked sialic acid. This dataset presents the analyzed RNA
sequencing data of α2,6-linked sialic acid-high and -low young and old
murine T cells.