KEGG group clustering of significantly altered hypothalamic proteins in tgHD rats compared to wild-type controls.

KEGG group clusters were only extracted from the differentially-regulated protein list if at least two proteins were present in each group with a compound probability of p≥0.05. To account for both KEGG enrichment (R: Observed expression frequency/Expected expression frequency) and compound probability (p) of clustered proteins, a hybrid score was used. Hybrid score = R * −log10(p).