Additional file 1 of Multivariate GWAS of Alzheimer’s disease CSF biomarker profiles implies GRIN2D in synaptic functioning

Additional file 1: Table S1. Participant Characteristics CSF Biomarker Sample. Table S2. Participant Characteristics GWAS Discovery Sample. Table S3. Participant Characteristics GWAS Replication Sample. Table S4. Local heritability and variance explained. Table S5. PCA loadings (individual cohorts). Table S6. Sex differences in CSF biomarker PCs and associations with Alzheimer’s disease. Table S7. Comparison of PCA-based GWAS results vs. single biomarker GWAS results. Table S8. Comparison of meta-analysis results using fixed effect vs. random effects models. Table S9a. PC5 top hits in meta-analysis split by discovery datasets. Table S9b. PC5 non-AD synaptic functioning replication and meta-analysis for top SNPs (p < 10E-3). Table S9c. SNP-based association results in Knight-ADRC dataset in GRIN2D region (bold font highlights nominally significant signals). Table S10. TWAS Fine-mapping analyses. Table S11. Gene-set enrichment analyses based on PC-based GWAS (top 20 gene sets [by P-value] are shown; bold font = significant after FDR [0.05]).