VTN (vitronectin) binds Integrin alphaVbeta3, alphaVbeta5, alphaVbeta8

Integrin alphaVbeta3 is highly expressed on osteoclasts, bone resorbing cells and is upregulated during vascular damage, angiogenesis and certain type of malignancies. It binds to vitronectin by recognizing the conserved RGD sequence within the N-terminal region. Integrin alphaVbeta3 plays an important role in signal transduction and regulation of osteoclast function. The integrin alphaVbeta5 receptor also interacts with vitronectin, promoting cell spreading. Integrin alphaVbeta8 can bind vitronectin as well as fibrin.

整合素αVβ3在破骨细胞、骨吸收细胞中高度表达，并在血管损伤、血管生成及某些类型的恶性肿瘤发生时上调。该整合素通过识别N端区域内的保守RGD序列与纤维连接蛋白结合。整合素αVβ3在信号传导和破骨细胞功能调节中发挥着至关重要的作用。整合素αVβ5受体亦与纤维连接蛋白相互作用，促进细胞扩散。整合素αVβ8能够与纤维连接蛋白以及纤维蛋白结合。