Crystal structure of PPARgamma with the ligand FS214

Crystal structure of PPARgamma with the ligand FS214 Descriptor: (2R)-3-phenyl-2-{[2'-(propan-2-yl)biphenyl-4-yl]oxy}propanoic acid, Peroxisome proliferator-activated receptor gamma Authors: Pochetti, G, Montanari, R, Loiodice, F, Fracchiolla, G, Laghezza, A, Carbonara, G, Piemontese, L, Lavecchia, A, Novellino, E. Deposit date: 2012-03-13 Release date: 2013-01-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: New 2-(Aryloxy)-3-phenylpropanoic Acids as Peroxisome Proliferator-Activated Receptor alpha/gamma Dual Agonists Able To Upregulate Mitochondrial Carnitine Shuttle System Gene Expression. J.Med.Chem., 56, 2013

结合配体FS214的过氧化物酶体增殖物激活受体γ（Peroxisome proliferator-activated receptor gamma, PPARγ）的晶体结构。描述符：(2R)-3-苯基-2-{[2'-(异丙基)联苯-4-基]氧基}丙酸。作者：Pochetti, G、Montanari, R、Loiodice, F、Fracchiolla, G、Laghezza, A、Carbonara, G、Piemontese, L、Lavecchia, A、Novellino, E。存储日期：2012-03-13；发布日期：2013-01-23；最后修改日期：2024-02-28。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.5埃。引用文献：《新型2-(芳氧基)-3-苯基丙酸类过氧化物酶体增殖物激活受体α/γ双重激动剂可上调线粒体肉碱穿梭系统基因表达》，J.Med.Chem., 56, 2013。