首页/数据集/Nuclear PKM2 can Function as a Molecular Platform to Stabilize the GATA4/6 Transcription Factors and also Promote MDM2-Mediated P53 Reduction in Cardiomyocytes; Implications for Heart Failure

Nuclear PKM2 can Function as a Molecular Platform to Stabilize the GATA4/6 Transcription Factors and also Promote MDM2-Mediated P53 Reduction in Cardiomyocytes; Implications for Heart Failure

NIAID Data Ecosystem2026-03-13 收录

心力衰竭分子机制

细胞转录调控

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP382828 数据链接链接失效反馈

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资源简介：

Project aim is to better understand the molecular pathways and regulators of heart failur

应用场景：

创建时间：

2022-08-05

细胞转录调控

ChIP-seq分析

Cytotoxic T Lymphocytes (CTLs) are effector CD8+T cells that eradicate infected and malignant cells from organism. We analyze the role of the transcription factor NFATc1 in activation and cytotoxicity

NIAID Data Ecosystem20

Genome-wide analysis of vitamin D receptor (VDR) target genes in THP-1 monocytic leucemia cells. Homo sapiens

维生素D受体靶基因鉴定

细胞转录调控

Identification of primary target genes of vitamin D receptor (VDR) in an immune-related cellular model (THP-1 cells) to study, in conjunction with VDR binding data from ChIP-seq, the genome-wide mecha

NIAID Data Ecosystem20

Genome-wide ETS-1 binding profile to chromatin in human CD4+ T lymphocytes [ChIP-seq]

细胞转录调控

ChIP-seq分析

In response to pathogenic threats, naÃ¯ve T cells rapidly transition from a quiescent to activated state, yet the underlying mechanisms are incompletely understood. We investigated the dynamics of mRN

NIAID Data Ecosystem10

Temporal analysis of RNA turnover in Interferon Gamma treated bone marrow-derived macrophages

RNA周转动力学

细胞转录调控

Bone Marrow derived macrophages (BMDM) were grown using L929 conditioned medium. On day 7, BMDM were mock-treated (16x 15cm dishes) or treated (16x 15cm dishes) with 10U/ml interferon gamma at time ze

DataCite Commons2025-04-24 更新20

An activation-induced immunoregulatory and tissue-residency program modulated by c-MAF in human memory Th17 cells [ChIP-seq] [RNA-seq]

细胞转录调控

Th17细胞功能

T cell effector function is largely mediated through the release of pro-inflammatory cytokines that need to be tightly regulated to avoid tissue damage. Here we show that the anti-inflammatory cytokin

NIAID Data Ecosystem10

Nuclear PKM2 can Function as a Molecular Platform to Stabilize the GATA4/6 Transcription Factors and also Promote MDM2-Mediated P53 Reduction in Cardiomyocytes; Implications for Heart Failure

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