Crystal Structure of EGFR-T790M/V948R in Complex with Poziotinib

Crystal Structure of EGFR-T790M/V948R in Complex with Poziotinib Descriptor: 1,2-ETHANEDIOL, 1-[4-[4-[[3,4-bis(chloranyl)-2-fluoranyl-phenyl]amino]-7-methoxy-quinazolin-6-yl]oxypiperidin-1-yl]propan-1-one, Epidermal growth factor receptor, ... Authors: Niggenaber, J, Mueller, M.P, Rauh, D. Deposit date: 2020-08-25 Release date: 2022-02-23 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors. J.Med.Chem., 65, 2022

表皮生长因子受体（Epidermal Growth Factor Receptor, EGFR）-T790M/V948R与波奇替尼（Poziotinib）复合物的晶体结构 描述项：1,2-乙二醇、1-[4-[4-[[3,4-二氯-2-氟苯基]氨基]-7-甲氧基喹唑啉-6-基]氧基哌啶-1-基]丙-1-酮、表皮生长因子受体等。作者：Niggenaber J、Mueller M.P、Rauh D。存库日期：2020-08-25；发布日期：2022-02-23；最后修改日期：2024-11-06。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å）。引用文献：《靶向表皮生长因子受体外显子20插入突变的野生型 sparing抑制剂研究洞察》，J.Med.Chem.，第65卷，2022年。