transcriptome analysis of pulmonary arteries in CD11c-Cre+ Zc3h12aflox/flox

Pulmonary arterial hypertension (PAH) is a subgroup of pulmonary hypertension characterized by progressive elevation of pulmonary arterial resistance due to vascular remodeling and right-heart failure. Inflammatory responses and cytokines are associated with PAH, although the pathogenesis of PAH is not fully understood. Regnase-1 is critical for immune regulation by acting as an RNase controlling mRNAs encoding genes related to immune reactions. We discovered that CD11c-Cre+ Zc3h12aflox/flox mice spontaneously developed PAH, which recapitulated the pathology of severe PAH patients, and Regnase-1 expressed in alveolar macrophages are critical for the development of PAH. Transcriptomic analysis of pulmonary arteries from these mice revealed that some of inflammatory cytokines and growth factors from Regnase-1 deficient alveolar macrophages influenced into the regulation of PAH.