Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Protein Data Bank Japan2023-12-13 更新2026-03-21 收录

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Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors Descriptor: 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE, SERINE/THREONINE-PROTEIN KINASE CHK1 Authors: Matthews, T.P, Klair, S, Burns, S, Boxall, K, Cherry, M, Fisher, M, Westwood, I.M, Walton, M.I, McHardy, T, Cheung, K.-M.J, Van Montfort, R, Williams, D, Aherne, G.W, Garrett, M.D, Reader, J, Collins, I. Deposit date: 2009-07-03 Release date: 2009-07-28 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.43 Å) Cite: Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening. J.Med.Chem., 52, 2009

检查点激酶1（checkpoint kinase 1，Chk1）与抑制剂结合的晶体结构描述：抑制剂为1-[(2S)-4-(5-溴-1H-吡唑并[3,4-b]吡啶-4-基)吗啉-2-基]甲胺，靶蛋白为丝氨酸/苏氨酸蛋白激酶CHK1 作者：Matthews, T.P.、Klair, S.、Burns, S.、Boxall, K.、Cherry, M.、Fisher, M.、Westwood, I.M.、Walton, M.I.、McHardy, T.、Cheung, K.-M.J.、Van Montfort, R.、Williams, D.、Aherne, G.W.、Garrett, M.D.、Reader, J.、Collins, I. 沉积日期：2009-07-03 发布日期：2009-07-28 最后修改日期：2023-12-13 实验方法：X射线衍射（分辨率2.43埃）引用文献：通过模板筛选法识别检查点激酶1抑制剂，《药物化学杂志》（J.Med.Chem.），第52卷，2009年

创建时间：

2009-07-03