Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118

Toxoplasma Gondii CDPK1 in complex with inhibitor LZH118 Descriptor: 1-tert-butyl-N~3~-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine, CALCIUM ION, Calmodulin-domain protein kinase 1 Authors: El Bakkouri, M, Lovato, D, Loppnau, P, Lin, Y.H, Rutaganaria, F, Lopez, M.S, Shokat, L, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Sibley, D, Hui, R, Walker, J.R, Structural Genomics Consortium (SGC) Deposit date: 2017-06-22 Release date: 2017-08-30 Last modified: 2026-05-20 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. J.Med.Chem., 60, 2017

刚地弓形虫（Toxoplasma Gondii）钙调蛋白结构域蛋白激酶1（Calmodulin-domain protein kinase 1, CDPK1）与抑制剂LZH118的复合物结构。描述项：1-叔丁基-N³-(3-氯苯基)-1H-吡唑并[3,4-d]嘧啶-3,4-二胺、钙离子。作者：El Bakkouri M、Lovato D、Loppnau P、Lin Y.H.、Rutaganaria F、Lopez M.S.、Shokat L、Bountra C、Edwards A.M.、Arrowsmith C.H.、Sibley D、Hui R、Walker J.R.、结构基因组学联合体（Structural Genomics Consortium, SGC）。提交日期：2017年6月22日；发布日期：2017年8月30日；最后修改日期：2023年10月4日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.4埃（Å）。引用文献：刚地弓形虫CDPK1与抑制剂LZH118的复合物结构，待发表。