Effects of lactoferrin on hepatic mediators in HFCS-induced murine HMMS.

Following eight weeks of lactoferrin administration (0, 50, 100, and 200 mg/kg), levels of hepatic LPS (hLPS), hTG, hIL-1β, hIL-6, hTNF-α, hMCP-1, hIL-4, hIL-13, hIL-33, and hTSLP were significantly higher in the control group than in the naïve group (P<0.05). Hepatic adiponectin (hAdn) was significantly lower in the control group than in the naïve group (P<0.05). There was no significant difference in hepatic bovine lactoferrin (hbLf) between the control and naïve groups. hLPS, hTG, hIL-1β, hTNF-α, hMCP-1, hIL-4, hIL-13, hIL-33, and hTSLP were significantly lower in the lactoferrin treatment groups (50, 100, and 200 mg/kg) than the control group (P<0.05). hIL-6 was significantly lower than the control only in the lactoferrin group receiving 100 mg/kg. hAdn was significantly higher than the control group in the 100 and 200 mg/kg lactoferrin groups (P<0.05). hbLf was significantly higher in the lactoferrin groups than the control group, in a dose-dependent manner. Data are presented as the mean ± SD (n = 10), and were analyzed with one-way ANOVAs and Duncan's multiple range test. a–d: Different letters in the same row indicate a significant difference (P<0.05).