Homo sapiens Raw sequence reads. Homo sapiens

We have recently shown that fluoxetine (FX) exerted potent anti-inflammatory action on cultured human epidermal keratinocytes, and it also suppressed the toll-like receptor 3 activator polyinosinic:polycytidylic acid (p(I:C))-induced release of the itch-mediator endothelins via the indirect inhibition of the phosphoinositide 3-kinase (PI3K) pathway. Importantly, besides its role in shaping immune, PI3K pathway is a positive regulator of proliferation in epidermal keratinocytes. Moreover, it has already been shown to play an important role in promoting proliferation of lesional keratinocytes in psoriasis. Thus, within the confines of the current, highly focused follow-up study, we aimed to assess whether potent anti-inflammatory concentration (14 mikorM) of FX influences proliferation and/or differentiation of human epidermal keratinocytes