Epigenome analysis of ischemic stroke patients

We performed a genome-wide methylation study in whole-blood DNA from 404 ischemic stroke patient cohort, distributed across 3 ischemic stroke subtypes: Large-artery atherosclerosis (n=132), Small-artery disease (n=141) and Cardio embolic (n=127) . Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites. We performed a genome-wide methylation study in whole-blood DNA from 185 ischemic stroke patient cohort. Illumina HumanMethylation450 BeadChip array was used to measure DNA methylation in CpG sites. Bisulphite converted DNA from the 404 samples were hybridised to the Illumina HumanMethylation450 BeadChip array Bisulphite converted DNA from the additional 185 samples [replication cohort] were hybridised to the Illumina HumanMethylation450 BeadChip array Please note that, for the replication cohort [GSM3026613-GSM3026797]; The 'Average Beta normalized data' is provided in the betas_normalized_meneas_185.txt & pval_detection_meneas_185.txt Raw 'unmethylated and methylated signal intensities' data is provided in meth_raw_meneas_185.txt & unmeth_raw_meneas_185.txt, and idat files.