Cell survival data from literature chosen for performance tests.

This table presents experimental data which were chosen for the examination of the kinetically extended GLOBLE. The treated cell lines and the dose rates that were applied during the dose rate effect experiments are listed. In case that survival probabilities after split dose experiments were presented in the publication, the applied doses are noted in the last column. The expected bias in measurements due to cell cycle effects is categorized as follows: “None1”: Synchronization in G1; “None2”: The population doubling time is much larger than the maximum irradiation time and the applied dose rates make cell cycle effects unlikely; “Unlikely”: The applied dose rates make cell cycle effects unlikely; “Not evident”: The authors state that no bias is evident in the data; “Possible”: The authors state that cell cycle effects cannot be ruled out. For the quantitative investigations of the GLOBLE, the HX99 cell line was excluded. For more explanations see text.