Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity.

Protein Data Bank Japan2024-02-28 更新2026-03-21 收录

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Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Descriptor: (1R,5S,6s)-3-[5-chloro-6-ethyl-2-(pyrimidin-5-yloxy)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-amine, DNA gyrase subunit B, GLYCEROL Authors: Bensen, D.C, Chen, Z, Tari, L.W. Deposit date: 2012-08-01 Release date: 2013-02-13 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity. Bioorg.Med.Chem.Lett., 23, 2013

DNA旋转酶B与拓扑异构酶IV的吡咯并嘧啶类抑制剂第一部分：具有强效广谱酶活性的双靶点药物的结构导向发现与优化。描述物：(1R,5S,6s)-3-[5-氯-6-乙基-2-(嘧啶-5-氧基)-7H-吡咯并[2,3-d]嘧啶-4-基]-3-氮杂双环[3.1.0]己烷-6-胺、DNA旋转酶亚基B（DNA gyrase subunit B）、甘油（GLYCEROL）作者：Bensen, D.C.、Chen, Z.、Tari, L.W. 入库日期：2012-08-01 发布日期：2013-02-13 最后修改日期：2024-02-28 检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å 引用文献：DNA旋转酶B（GyrB）与拓扑异构酶IV（ParE）的吡咯并嘧啶类抑制剂第一部分：具有强效广谱酶活性的双靶点药物的结构导向发现与优化。发表于《Bioorg.Med.Chem.Lett.》23卷，2013年

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2012-08-01