TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells. TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells

RNA-seq analysis to understand the regulation of genes by TET1 in mouse lungs and human bronchial epithelial cells. Overall design: An allergic airway inflammation model was established in Tet1+/+ mice and Tet1-/- mice using house dust mite allergen with appropriate controls. Lung RNA were extracted and compared using RNA-seq. In addition, endogenous TET1 expression was activated in human bronchial epithelial cells by dCasCRISPR for 24 hrs. RNA was extracted and compared between control and TET1 activated cells.