SCL and LMO1 reprogram thymocytes into self-renewing cells.. Mus musculus
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA301090
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资源简介：
The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Overall design: Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.
创建时间：
2015-11-04
