Data from: Histopathological investigation of wound healing activities of <em>Lucilia sericata</em> larva and <em>Achillea sintenisii</em> extract combinations in diabetic rat wound model

Chronic wounds are a significant health concern, especially in patients with metabolic diseases like diabetes, and they impose a substantial financial burden on individuals and healthcare systems. Alongside conventional treatments, complementary therapies are increasingly used to support wound healing. Maggot Debridement Therapy (MDT), utilizing the larvae of Lucilia sericata, is a globally recognized method for treating non-healing wounds. These larvae secrete substances with antifungal, antibacterial, and anti-inflammatory properties. Herbal remedies also play a role in chronic wound care, with various Achillea species traditionally used for medicinal purposes. This study investigated the wound healing effects of a pomade combining L. sericata larval secretions and Achillea sintenisii plant extract, compared to Furacin®, a commercial wound healing cream. Excisional wounds were created on diabetic Wistar albino rats, which were divided into four groups: DF (Furacin®), DM (L. sericata secretion), DA (A. sintenisii extract), and DM+DA (combined treatment). Wound area, contraction rates, and histological analyses were conducted to evaluate treatment efficacy. Results showed that both DM and DA treatments were more effective than Furacin® (DF), with DM outperforming DA. The most rapid and effective healing occurred in the DM+DA group, indicating a synergistic effect between the animal and plant-based therapies. This is the first comparative study evaluating the combined wound healing potential of these agents in a chronic wound model. The findings suggest that L. sericata secretions and A. sintenisii extract could lead to the development of affordable, accessible, and effective natural products for chronic wound care. These results may contribute to innovative treatment options in both veterinary and human medicine.