hccTAAb Atlas: An Integrated Knowledge Database for Tumor-Associated Autoantibodies in Hepatocellular Carcinoma

Tumor-associated autoantibodies (TAAbs) have demonstrated
potential
as biomarkers for cancer detection. However, the understanding of
their role in hepatocellular carcinoma (HCC) remains limited. In this
study, we aimed to systematically collect and standardize information
about these TAAbs and establish a comprehensive database as a platform
for in-depth research. A total of 170 TAAbs were identified from published
papers retrieved from PubMed, Web of Science, and Embase. Following
normative reannotation, these TAAbs were referred to as 162 official
symbols. The hccTAAb (tumor-associated autoantibodies in hepatocellular carcinoma) atlas was developed using the R Shiny framework
and incorporating literature-based and multiomics data sets. This
comprehensive online resource provides key information such as sensitivity,
specificity, and additional details such as official symbols, official
full names, UniProt, NCBI, HPA, neXtProt, and aliases through hyperlinks.
Additionally, hccTAAb offers six analytical modules for visualizing
expression profiles, survival analysis, immune infiltration, similarity
analysis, DNA methylation, and DNA mutation analysis. Overall, the
hccTAAb Atlas provides valuable insights into the mechanisms underlying
TAAb and has the potential to enhance the diagnosis and treatment
of HCC using autoantibodies. The hccTAAb Atlas is freely accessible
at https://nscc.v.zzu.edu.cn/hccTAAb/.