Increased Reflux Secondary Bile Acids are Associated with Shifts to the Microbiome and Transcriptome in Barrett's Esophagus

Bile acids comprise a major component of refluxate in GERD, the major rest factor for Barrett's esophagus and esophageal adenocarcinoma. Bile acids are metabolized by bacteria, and bacterial composition is also impacted by exposure to bile acids. To understand how these factors may interrelate in EAC development, we performed a comprehensive assessment of the microbiome, refluxate bile acids, and tissue gene expression in patients with BE, dysplasia, and EAC.