Chrnb3

Predicted to enable acetylcholine binding activity and acetylcholine-gated monoatomic cation-selective channel activity. Predicted to contribute to acetylcholine receptor activity and heterocyclic compound binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Is active in dopaminergic synapse. Is expressed in intestine; liver; nervous system; and retina. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; bipolar disorder; cocaine dependence; depressive disorder; and nicotine dependence. Orthologous to human CHRNB3 (cholinergic receptor nicotinic beta 3 subunit). [provided by Alliance of Genome Resources, Nov 2024]

此基因预测可激活乙酰胆碱结合活性及乙酰胆碱门控的单原子阳离子选择性通道活性。预测其对乙酰胆碱受体活性与杂环化合物结合活性有所贡献。参与化学突触传递的前突触调节。在多巴胺能突触中表现出活性。表达于肠道、肝脏、神经系统及视网膜。人类同源基因与多种疾病相关，包括酒精依赖、双相情感障碍、可卡因依赖、抑郁症及尼古丁依赖。与人类CHRNB3（胆碱能受体烟碱型β3亚单位）同源。[由基因组资源联盟提供，2024年11月]