Additional file 1 of Sex differences in expression of immune elements emerge in children, young adults and mice with osteosarcoma

Additional file 1: Supplemental Figure 1. Overall survival for A. All TARGET-OS cases with survival information and B. TARGET-OS cases with gene expression data and survival information. Supplemental Figure 2. Gene expression in TARGET-OS patients. A. Heatmap of all differentially expressed genes (adj. p-value <0.05) identified between male. Supplemental Figure 3. Survival differences among female TARGET-OS cases with high LM22 M2 macrophage scores. Supplemental Table 1. TARGET osteosarcoma gene expression in males compared to females, ranked by adjusted p-value. Supplemental Table 2. Mouse osteosarcoma gene expression in males compared to females, ranked by adjusted p-value (*indicates gene also found significant differentially expressed by sex in TARGET OS). Supplemental Table 3. Healthy adult osteoblast gene expression in males compared to females, ranked by adjusted p-value (GEO: GSE15678) (*indicates gene also found significant differentially expressed by sex in TARGET OS). Supplemental Table 4. TARGET osteosarcoma Ingenuity Pathway Analysis pathways that differed significantly by sex, ranked by p-value. Supplemental Table 5. Ingenuity Pathway Analysis in mice for pathways that differed significantly by sex, ranked by p-value. Supplemental Table 6. Results from TARGET-OS LM22 analysis. Supplemental Table 7. Results from mouse-OS LM22 analysis. Supplemental Table 8. Top 10 GSEA C7 gene sets ranked by FWER for TARGET-OS females and males. Supplemental Table 9. Top 10 GSEA C7 gene sets ranked by FWER for mouse-OS females and males.