The Cancer Genome Atlas Esophageal Carcinoma Collection

<p>The Cancer Genome Atlas Esophageal Carcinoma (TCGA-ESCA) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from <a href="http://cancergenome.nih.gov/">The Cancer Genome Atlas (TCGA)</a>. Clinical, genetic, and pathological data resides in the <a href="https://portal.gdc.cancer.gov/exploration?filters=%7B%22op%22%3A%22and%22%2C%22content%22%3A%5B%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.program.name%22%2C%22value%22%3A%5B%22TCGA%22%5D%7D%7D%2C%7B%22op%22%3A%22in%22%2C%22content%22%3A%7B%22field%22%3A%22cases.project.project_id%22%2C%22value%22%3A%5B%22TCGA-ESCA%22%5D%7D%7D%5D%7D">Genomic Data Commons (GDC) Data Portal</a> while the radiological data is stored on The Cancer Imaging Archive (TCIA). </p><p>Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes.  Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type.  For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols.  In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial. </p><h3>CIP TCGA Radiology Initiative</h3><p>Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource.  Learn more about the <a href="/display/Public/CIP+TCGA+Radiology+Initiative">CIP TCGA Radiology Initiative</a>.</p>

《癌症基因组图谱食管癌（TCGA-ESCA）数据集》系一项旨在构建研究共同体、将癌症表型与基因型相联系的大型研究计划的重要组成部分。该计划通过提供与来自《癌症基因组图谱》（TCGA）受试者相匹配的临床图像，致力于连接癌症表型与基因型。临床、遗传和病理数据存储于《基因组数据共享（GDC）数据门户》中，而影像数据则保存在《癌症影像档案》（TCIA）中。通过匹配的TCGA患者标识符，研究人员得以探索TCGA/TCIA数据库中组织基因型、影像表型与患者预后之间的相关性。为达成其累计目标，即通常每种癌症类型约500个样本，TCGA从全球多个地点收集组织样本。因此，图像数据集在扫描模式、制造商和采集协议方面也表现出极高的异质性。在大多数情况下，图像的采集是作为常规护理的一部分，而非作为受控研究或临床试验的一部分。此外，《CIP TCGA影像学倡议》正在组建和治理影像来源机构（ISS）小组，该小组由为特定癌症类型向档案提供影像数据的机构成员组成。ISS小组模仿TCGA分析小组的模式，有机会根据上表中的指南为特定癌症类型发表标记论文。这一机会将促进更多机构参与构建这些多机构数据集，使其成为开放社区资源。欲了解更多关于《CIP TCGA影像学倡议》的信息，请访问相关链接。