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The mutational landscape of hepatocarcinogeneis in a rat model

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NIAID Data Ecosystem2026-04-25 收录
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Hepatocellular carcinoma (HCC) initiation is characterized by the sequential stepwise accumulation of molecular alterations. However, the earliest events during the dynamic temporal trend of hepatocarcinogenesis are still unknown. Using a diethylnitrosamine (DEN)-induced rat HCC model, we report a comprehensive genomic landscape of liver tissues at the stages of hepatitis, cirrhosis, and HCC.

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2020-12-12
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