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Classification of immunodeficiencies and DNA-repair dysfunction via antibody recombination scars

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NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP547860
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we developed and tested a methodology (SWIBRID = SWItch joint BReakpoint IDentification) that harnesses memory B cells for the personalized assessment of immunocompetence and DNA double-strand break repair. Starting from a single, blood-based PCR-reaction, our dedicated bioinformatics pipeline systematically measures the quantity and quality of in vivo generated class-switch recombination joints.
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2025-10-20
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