Schematic representation of Pyk2 phosphorylation triggered by Src.
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https://figshare.com/articles/dataset/_Schematic_representation_of_Pyk2_phosphorylation_triggered_by_Src_/1645147
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In the inactive state, Pyk2 is in an unphosphorylated state. Upon integrin ligand binding, Src phosphorylates Y402, creating a binding site for the SH2-domain of Src, and enabling further phosphorylation of Pyk2 by Src, including at site Y579 (and likely at Y580, although not studied here). As shown by others [21,22] phosphorylated and activated Pyk2 dimerizes or oligomerizes with itself, leading to further phosphorylation of Pyk2 via auto/trans-phosphorylation.
创建时间：
2016-03-16
