Dopamine receptors are involved in GABAergic transmission onto Somatostatin Interneuron

<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:0.0001pt;line-height:normal">Dopamine is well known to modulate brain functions such as memory and
learning; therefore, its involvement in these processes has been intensively
studied. However, many studies into underlying mechanisms have been largely
focused on glutamatergic synapses and their plasticity. Much less is known
about the dopaminergic modulation of inhibitory transmission and plasticity at
synapses formed by distinct GABAergic interneurons targeting different cells.
Herein, we addressed the role of dopamine receptors (DRs) in inhibitory transmissions
at synapses between interneurons in the CA1 region. Activation or blockade of DRs
did not affect the amplitude of miniature inhibitory postsynaptic currents (mIPSCs),
while the mIPSCs frequency was reduced after DRs antagonist application, and decay
kinetics was prolonged when DRs agonist was used.  It indicates a complex pre- and postsynaptic
mechanism. </p>