Zinc oxide quantum dots may provide a novel potential treatment for antibioic-resistance Streptococcus agalactiae in lama glama

Streptococcus agalactiae is a significant pathogen that can affect both human beings and animals. The extensive use of antibiotics has resulted in antibiotic resistance currently. In our previous research, we found that Zinc oxide quantum dots (ZnO QDs) has an effectively inhibit effect for antibiotic-resistant Staphalococcus aureus. In this study, a strain of Streptococcus agalactiae WJYT1 with a broad antibiotic-resistant spectrum was isolated and identified from an lama glama in Sichuan Agricultural University Teaching Animal Hospital. The genome for resistance and virulence genes were analyzed. The antibacterial effects and anti-virulence mechanism of ZnO QDs for S. agalactiae WJYT1 was next investigated. The results showed that the genome of S. agalactiae WJYT1 is 1,943,955bp containing 22 resistance genes and 95 virulence genes. ZnO QDs have a good antibacterial effect against S. agalactiae WJYT1 by decreasing bibA, hylB, sip and cip, which provides a novel potential treatment for S. agalactiae.