Cancer-associated chromosomal rearrangements can result in the expression of numerous pathogenic fusion proteins. The mechanisms via which the fusion proteins contribute to oncogenesis are largely unk
Poly (ADP-ribose) polymerase 1 (PARP-1) is a critical enzyme involved in DNA damage repair and recombination, and shows great potential for drug development in the treatment of cancers with defective
ABSTRACT The aims of this study were to synthesize a series of thiosemicarbazones and their thiazole derivatives, to investigate their cytotoxic activity against three human cancers and normal (Vero c
The studied agents (NHAPI and Dp44mT and their fully coordinated iron (Fe) or copper (Cu) complexes and tamoxifen (TMX)) were incubated with T47D cells for 72 h at 37°C. Cell viability was determined
