Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F

Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Brouwer, P.J.M, Perrett, H.R, Ward, A.B. Deposit date: 2024-07-05 Release date: 2024-09-25 Last modified: 2025-05-28 Method: ELECTRON MICROSCOPY (3 Å) Cite: Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses. Cell Rep, 43, 2024

本数据集为谱系IV型拉沙病毒 (Lassa virus) 糖蛋白 (glycoprotein)（Josiah株）与单克隆抗体 (monoclonal antibody) 8.9F的复合物。其修饰聚糖描述如下：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-[α-L-吡喃岩藻糖-(1→6)]2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖等。作者：Brouwer P.J.M、Perrett H.R、Ward A.B。提交日期：2024-07-05；发布日期：2024-09-25；最后修改日期：2025-05-28。研究方法：电子显微镜 (electron microscopy)（分辨率3埃）。引用文献：《通过结构解析疫苗诱导的多克隆抗体 (polyclonal antibody) 应答明确拉沙病毒中和的瓶颈与机遇》，《细胞报告（Cell Reports）》，第43卷，2024年。