Models of Magnetic Nanoparticles and Vascular Tissue

Magnetically guided drug delivery systems offer localized, targeted drug delivery using magnetic nanoparticles. The capture of the nanoparticles by the stent struts, under relevant magnetic field and blood velocity was modeled using COMSOL Multiphysics. The coronary artery was modeled using a 2D axisymmetric model with stainless steel stent struts. A Magnetic field of 1 T was applied to magnetize the stent struts. Three different strut geometries were compared for their effect of the capture efficiency. The model had a capture efficiency of 34-42%. Ex vivo organ culture studies using porcine right coronary arteries were performed to validate the capture efficiency modeled. The arteries were conditioned dynamically in an organ culture bioreactor and had an average capture efficiency of 31%.