Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1

Lactobacillus CASEI Thymidylate Synthase Ternary Complex With DUMP and the Phtalimidic Derivative 14C in Multiple Binding Modes-Mode 1 Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione, Thymidylate synthase Authors: Leone, R, Mangani, S, Cancian, L, Costi, M.P, Luciani, R, Ferrari, S. Deposit date: 2008-01-18 Release date: 2009-01-20 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening J.Med.Chem., 54, 2011

干酪乳杆菌CASEI（Lactobacillus CASEI）胸苷酸合酶（Thymidylate Synthase）与脱氧尿苷5'-单磷酸（DUMP）及14C标记的邻苯二甲酰亚胺衍生物形成的三元复合物的多种结合模式——模式1 数据集描述符：2'-脱氧尿苷5'-单磷酸、2-(2-氯吡啶-4-基)-4-甲基-1H-异吲哚-1,3(2H)-二酮、胸苷酸合酶（Thymidylate Synthase）。作者：Leone R、Mangani S、Cancian L、Costi M.P.、Luciani R、Ferrari S。保藏日期：2008年1月18日；发布日期：2009年1月20日；最后更新日期：2023年11月1日。实验方法：X射线衍射（分辨率2.6 Å）。引用文献：通过X射线晶体学筛选鉴定抑制细菌胸苷酸合酶的N-苯基邻苯二甲酰亚胺类化合物的结合模式，J.Med.Chem., 54, 2011。